amnestic mild cognitive impairment and mild Alzheimer's disease structure and function of the MRI

Title: amnestic mild cognitive impairment and mild Alzheimer's disease structure and function of the MRI Author: Li Yadi Degree-granting units: Fudan University Keywords: mild cognitive impairment;; Alzheimer's disease;; magnetic resonance imaging;; gray matter;; voxel-based morphological analysis; mild cognitive impairment;; Alzheimer's disease;; magnetic resonance imaging ;; white matter;; diffusion tensor;; voxel-based; mild cognitive impairment;; Alzheimer's disease;; functional magnetic resonance imaging;; resting state;; correlation analysis;; independent component analysis Abstract:
The first part of the aMCI and mild AD whole-brain voxel-based MRI study of morphological
Purpose: To use magnetic resonance imaging study of 3D T1WI amnestic mild cognitive impairment (amnestic-type mild cognitive impairement, aMCI), mild Alzheimer's disease (Alzheimer's disease, AD) patients compared with normal gray matter volume changes in the elderly characteristics. Methods: 3.0T MRI, 33 cases of aMCI patients, 32 patients with mild AD patients and 31 normal older people three-dimensional T1WI scan, using the DARTEL toolbox Neodymium Magnets based SPM5 the structure of scanning images obtained pretreatment, and then the aMCI group, mild AD group and the control group the volume of whole brain gray matter voxel-based statistical comparison. Results: Compared with normal old age, aMCI group left hippocampus, parahippocampal gyrus, lingual gyrus, superior temporal gyrus, bilateral insula, temporal gyrus gray matter volume atrophy and other structures, the difference was statistically significant (P <0.01 , FDR corrected, K ≥ 50 voxels). Mild AD group of bilateral hippocampus, parahippocampal gyrus and amygdala, bilateral thalamus, bilateral parietal cortex, temporal gray matter volume atrophy and other structures, frontal and occipital cortex also appeared in the gray matter atrophy, the difference was statistically significant ( P <0.05, FDR corrected, K ≥ 50 voxels). Conclusion: Voxel-based morphological study of early AD patients can be found in a wide range of brain gray matter atrophy and the fine structure, which will be more early, comprehensively and objectively reflect the aMCI, AD patients with mild brain structural changes.
The second part of the aMCI and mild AD whole-brain voxel-based DTI study
Objective: Magnetic resonance diffusion tensor imaging (DTI) techniques to explore the aMCI, AD patients with mild changes of white matter abnormalities. Methods: 3.0T MRI, 33 cases of aMCI patients, 32 patients with mild AD patients and 31 normal older people DTI examination. Use SPM5 analysis software, voxel-based analysis to compare differences in whole brain and changes in FA values. Results: Compared with normal old age, aMCI group of bilateral fronto-temporal lobe, the left suboccipital back to the narration quality, buckling the front of the tongue back to the narration of quality, quality narration fusiform gyrus, inferior parietal lobule, the right lateral ventricle trigone outside the top of the white matter FA values ​​lower, the difference was statistically significant (P <0.001, uncorrected, K ≥ 20 voxels). Mild AD group with bilateral frontal-temporal occipital lobe, hippocampus narration quality, buckle front, the corpus callosum, lateral triangle next to the voice-over quality, inferior parietal lobule, right precuneus and the wedge leaves, calcarine fissure adjacent white matter, left FA value reduced temporal dry side, the difference was statistically significant (P <0.001, uncorrected, K ≥ 20 voxels). The first part of this project appear more gray matter atrophy of parts, we found http://www.everbeenmagnet.com/en/products/110-sintered-neodymium-magnets that aMCI patients was reduced white matter FA values ​​of gray matter atrophy of the brain and brain regions most inconsistent, only in the left temporal lobe are similar differences in the regional area; mild AD patients was reduced white matter FA values ​​of gray matter atrophy of the brain and some of the same brain regions. Conclusion: Voxel-based whole brain analysis of FA maps to more objective and comprehensive that aMCI, AD patients with mild white matter abnormalities area. White matter changes in the pattern of gray matter atrophy patterns are not the same, may be the result of many factors.
The third part of the aMCI and mild AD, resting state fMRI study
Objective: to group independent component analysis (GroupICA), of aMCI and mild AD patients resting state characteristics of changes in brain function. Methods: 3.0T MRI, 33 cases of aMCI, 32 patients with mild AD patients and 31 normal older people resting state fMRI scan. The use of REST, GIFT, SPM5 analysis software, voxel-based whole brain analysis and comparison of resting-state functional changes in the network. Results: The analysis of seed-related and group independent component analysis identified the default mode of the normal elderly group similar network of brain regions, including: posterior cingulate (posterior cingulate cortex, PCC), wedge leaves and precuneus, inferior parietal lobule , medial prefrontal area (Dorsal-medial prefrontal cortex, DMPFC), dorsal lateral prefrontal area (Dorsal-lateral prefrontal cortex, DLPFC), part of the temporal occipital lobe (P <0.05, FWER, K ≥ 10 voxels), In addition to group independent component analysis also included bilateral thalamus, hippocampus, parahippocampal gyrus, insula. aMCI patients most of the default mode network activation of brain areas have emerged in the degree of reduction, and in the bilateral precuneus, wedge-leaf, the middle cingulate gyrus, putamen, striatum, the right inferior parietal lobule activation levels appear increased (P <0.05, FWER, K ≥ 10 voxels); aMCI patients was visual network BA (18,19), there have been active in the region increased levels (P <0.001, uncorrected, K ≥ 10 voxels); light AD patients with two degrees of lateralization in the right middle frontal gyrus network (BA9), right inferior parietal lobule (BA40), left inferior parietal lobule (BA40) and the top of the lobular (BA7), left frontal lobe ( BA 6,9,8) and reduced activation of the right middle frontal gyrus (BA 10,46) activation increased (P <0.05, FWER, K ≥ 10 voxels). Default mode network of brain regions activated to reduce the level of the left hippocampus in addition to a few brain regions, the rest of the resting state network of brain regions dysfunction occurs before the morphological abnormalities; two networks laterality of brain areas are activated less not found significant gray matter atrophy. DTI found that the destruction of the structure connecting the abnormal functional connectivity provides anatomical evidence. Conclusion: The ICA can be grouped in aMCI, AD patients with mild brain structural abnormalities found in the resting state before the network characteristics of brain function have changed. MRI analysis of the joint structure and function to provide more information, the future research directions. Degree Year: 2009